This was something that really surprised me, I tried Two Notes wall of Sound with little expectation, you know how it is, give it a try, but Blimey, it knocked me over. This is what it looks like...

It simulates speaker cabinets, nope not very exciting, but if you are a guitarist, that is one thing you'll definitely take for granted, the impact of your speaker on your sound. You get a few free cabinets with the free software, then if you want any more you have to pay about 6 quid each, and if you sign up you'll get some excellent discount offers.
The Wall of Sound will make you realise how important that cone thing is in your live setup.
Here's how to use it...
Record your track, maybe just DI into your Audio Interface
Apply your Amp Sim, such as Amplitude, Plugin Alliance Rock Rack, Bias Amp, Scuffham
Turn off the Speaker in the Amp Sim
Add the Speaker Cab Sim after the Amp Sim.
I use the Wall of Sound on very many Guitar tracks, very often it does the trick better than EQ, and naturally changes the sound.
I thorough recommend it.
Let me know if you try this, I would be very interested in hearing your opinions and your exepriences.
I can also recommend some cabinets.